China (Mainland)
Sotorasib (AMG510) CAS NO.2296729-00-3
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- Product Details
Keywords
- Sotorasib
- AMG510
- 2296729-00-3
Quick Details
- ProName: Sotorasib (AMG510)
- CasNo: 2296729-00-3
- Molecular Formula: C30H30F2N6O3
- ProductionCapacity: Metric Ton/Day
- Purity: >97%
- LimitNum: 0 Metric Ton
Superiority
Biological Activity
| Description | Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound. | |
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| Targets |
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| In vitro |
AMG 510 inhibits SOS1-catalyzed nucleotide exchange of recombinant mutant KRAS (G12C/C118A) but had minimal effect on KRAS (C118A). AMG 510 also selectively impairs the viability of KRAS p.G12C mutant lines but does not affect cell lines with other KRAS mutations[1].
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| In vivo |
In preclinical tumor models, AMG 510 rapidly and irreversibly binds to KRAS (G12C), providing durable suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. Dosed orally (once daily) as a single agent, AMG 510 is capable of inducing tumor regression in mouse models of KRASG12C cancer[2]. |