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Home > Products >  MCC950 Sodium (CP-456773 Sodium)

MCC950 Sodium (CP-456773 Sodium) CAS NO.256373-96-3

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Keywords

  • MCC950 Sodium (CP-456773 Sodium)
  • CRID3 sodium salt
  • 256373-96-3

Quick Details

  • ProName: MCC950 Sodium (CP-456773 Sodium)
  • CasNo: 256373-96-3
  • Molecular Formula: C20H23N2O5S.Na
  • ProductionCapacity: Metric Ton/Day
  • Purity: >97%
  • LimitNum: 0 Metric Ton

Superiority

Biological Activity

Description MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes.
Targets
NLRP3 [1]
(in BMDM (bone marrow derived macrophages))		 NLRP3 [1]
(in HMDM)
7.5nM 8.1 nM
In vitro

MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.[1]
Cell Data
 
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse BMDM cells Function assay   30 mins   Inhibition of NLRP3 in mouse BMDM cells preincubated for 30 mins followed by ATP addition by ELISA analysis. IC50=0.0075 μM 26422006
mouse BMDM cells Function assay   30 mins   Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse BMDM assessed as reduction in NLRP3 inflammasome-induced IL-1beta production preincubated for 30 mins followed by NLRP3 stimulation with ATP by ELISA. IC50=0.0075 μM 27994733
INS-1 cells Function assay 0.01 μM 1 h   MCC950 inhibited not only inflammasome activation but also Ang II-induced IL-1β elevation and cell apoptosis in INS-1 cells. 30939192

... Click to View More Cell Line Experimental Data
Assay
Methods Test Index PMID
Western blot 28865486
Growth inhibition assay 27670879
Immunofluorescence 28865486
ELISA 28726778
In vivo MCC950 reduces interleukin-1β (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE). Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome. [1]

 

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