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Home > Products >  Trichostatin A (TSA)

Trichostatin A (TSA) CAS NO.58880-19-6

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Keywords

  • Trichostatin A
  • TSA
  • 58880-19-6

Quick Details

  • ProName: Trichostatin A (TSA)
  • CasNo: 58880-19-6
  • Molecular Formula: C17H22N2O3
  • Application: 58880-19-6
  • ProductionCapacity: Metric Ton/Day
  • Purity: 99.33%
  • LimitNum: 0 Metric Ton

Superiority

Biological Activity

Description Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM in cell-free assays.
Targets
HDAC [1]
(Cell-free assay)
~1.8 nM
In vitro

Trichostatin A inhibits the proliferation of eight breast carcinoma cell lines including MCF-7, T-47D, ZR-75-1, BT-474, MDA-MB-231, MDA-MB-453, CAL 51, and SK-BR-3 with mean IC50 of 124.4 nM (range, 26.4-308.1 nM), with more potency against cell lines that express ERα than the ERα-negative cell lines. Trichostatin A inhibits HDAC activity similarly in all the breast cancer cell lines with mean IC50 of 2.4 nM (range, 0.6-2.6 nM), and results in pronounced histone H4 hyperacetylation. [1] Unlike Trapoxin (TPX) and Chlamydocin which potently inhibit HDAC1 or HDAC4 but not HDAC6, Trichostatin A inhibits these HDACs to a similar extent with IC50 of 6 nM, 38 nM, and 8.6 nM, respectively. [2] Trichostatin A (100 ng/mL) treatment induces the expression of transforming growth factor β type II receptor (TβRII) in MIA PaCa-2 cells through the recruitment of p300 and PCAF into a Sp1-NF-Y HDAC complex that binds the DNA element of TβRII promoter, which is associated with a concomitant acetylation of Sp1 and an overall decrease in the amount of HDAC associated with the complex. [4]

Cell Data
 
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HeLa Growth Inhibition Assay 10/30/50 nM 72 h DMSO increases the number of MMP (ΔΨm) loss cells dose dependently 23165748
HeLa Growth Inhibition Assay 20 nM 72 h DMSO IC50 of 20nM 23165748
HeLa Growth Inhibition Assay 40 nM 48 h DMSO IC50 of 40nM 23165748

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot         31289542 27431944 23802098
Immunofluorescence     21122806 29045501 27957719
Growth inhibition assay     27571418 27548148 31289542
In vivo Administration of Trichostatin A at 0.5 mg/kg for 4 weeks displays potent antitumor activity in the N-methyl-N-nitrosourea carcinogen-induced rat mammary carcinoma model, without any measurable toxicity at doses up to 5 mg/kg. [1] Single intraperitoneal doses of 10 mg/kg Trichostatin A in nontransgenic and spinal muscular atrophy (SMA) model mice results in increased levels of acetylated H3 and H4 histones and modest increases in survival motor neuron (SMN) gene expression. Administration of Trichostatin A at 10 mg/kg/day improves survival, attenuates weight loss, and enhances motor behavior in the SMA model mice. [5]

 

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